Department Lecture Series
Tuesday February 19, 9:45 am, Smith 331

Microanalytical Tools to Investigate Cellular Signaling

Cells must receive and process information (growth factors, hormones, cytokines) arriving at their plasma membrane. To formulate a response to these stimuli, cells possess complex signaling circuitry. However, much remains unknown about these signal processing pathways. A key reason is the lack of high-throughput technologies to assess the state of these pathways at the level of a single cell. Array-based strategies for cells adherent to a surface and microfluidic methods for nonadherent cells have the potential to fulfill these needs. The lab is currently developing microanalytical platforms to analyze single adherent or nonadherent cells. Recent results on assay development in these devices will be presented.