This webpage was for the 2002 Conference. Please see: http://www.chem.indiana.edu/mecc for the 2003 Midwest Enzyme Chemistry Conference.

MECC is one of the most interesting and successful meetings for enzymologists. This year's annual gathering will feature a full day of presentations on the cutting edge of research in enzymology. A late afternoon poster session will include a wide range of structural, spectroscopic, synthetic and mechanistic studies on enzymes and their related chemistry.

Co-Organizers:

PROGRAM  (Program in PDF format)

Morning­ Norris Center, 1st Floor
7:30	Registration & Continental Breakfast, Purdue Room
8:45	Welcome: Marian Stankovich (Department of Chemistry, University of Minnesota)
Session 1: Computational Chemistry (McCormick Auditorium) Chair: Jan H. Jensen
9:00	BRIAN SHOICHET Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois “Structure, Function, and Inhibition of b-Lactamase”
9:30	JIALI GAO Department of Chemistry, University of Minnesota “Dynamics, Pathways, and Tunneling – A Computational Perspective of Enzyme Catalysis”
10:00	Coffee Break (Purdue Room)
Session 2: Observing Enzyme Mechanisms and Chemistry in Crystals (McCormick Auditorium) Chair: John Tanner
10:30	ANDREW MESECAR Department of Medicinal Chemistry and Pharmacognosy and the Center for Pharmaceutical Biotechnology, University of Illinois, Chicago “Making Molecular Movies of Enzyme Reaction Coordinates–This Isn’t Hollywood”
11:00	CAROLINE WILMOT and Arwen Pearson Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Twin Cities “Catching Catalysis in the Act: Using Single Crystal Kinetics to Trap Methylamine Dehydrogenase Reaction Intermediates for X-ray Structure Studies”
11:30	JUNG-JA P. KIM, Paul A. Hubbard, Rosemary Paschke, Anna L. Shen and Charles B. Kasper Department of Biochemistry, Medical College of Wisconsin, Milwaukee “Structure and Function of NADPH-Cytochrome P450 Reductase: Prototype for FMN- and FAD-Containing Enzymes”
12:00	Buffet Lunch (Garrett Evangelical Theological Seminary)
Afternoon– Norris Center, 1st and 2nd Floors
Session 3: General Session – Enzyme Mechanisms (McCormick Auditorium) Chair: Graham R. Moran
1:30	ANDREAS MATOUSCHEK Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois “Protein Unfolding in the Cell”
2:00	JON THORSON School of Pharmacy, University of Wisconsin, Madison “Natural Product Biosynthesis and Glycorandomization”
2:30	DONALD BECKER, Weidong Zhu, Dan Gu, Padmanetra Bellur, Berevan Baban, M. P. Vinod, Jeng-Jong Shieh, and John J. Tanner Department of Chemistry and Biochemistry, University of Missouri, St. Louis “Redox Regulation of the Multifunctional PutA Flavoprotein”
3:00	CELE ABAD-ZAPATERO Department of Structural Biology, Protein Crystallography Laboratory, Global Pharamceutical Research Division, Abbott Laboratories, Abbott Park, Illinois “Subtleties, Advances and Challenges in the Structure-Based Drug Design of Potent and Selective hPTP1B Inhibitors for the Treatment of Type II Diabetes”
3:30	Closing Remarks: Amy Rosenzweig (Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois)
3:45-6:00	Poster Session (Louis Room, 2nd Floor Norris Center)