The University of Minnesota has an outstanding High-Field NMR facility for Structural Biology, which is located in the Biochemistry Department. The facility is equipped with one a 700 MHz solid-state NMR, a 500 MHz, two 600 MHz and one 800 MHz spectrometers. The solid-state NMR is capable of running MAS and static samples while the solution instruments are equipped with multinuclear, triple axis gradient probes and with deuterium decoupling circuitry. Included in the current 5 year plan for upgrading this facility is the acquisition of cryoprobes (one has already been ordered) that will greatly improve the sensitivity of these instruments.

Experimental Approach

Solid-state NMR of membrane proteins in oriented lipid bilayers.

Solution NMR of membrane proteins in detergent micelles.