The focus of the Veglia Research Group is to study the structure, function and interactions of membrane proteins using solution NMR and solid-state NMR. Solution NMR studies of membrane proteins in detergent micelles allow the determination of high resolution structural and dynamics information, while solid-state NMR is used to obtain structural, dynamic, and orientational information about membrane proteins in a lipid membrane environment. We use both methods to study the functional interactions of membrane protein complexes. We develop computational methods to analyze our experimental results and use molecular dynamics simulations to support and enhance our results. Undergraduate and graduate students acquire a multidisciplinary background through the application of a broad range of biophysical and biochemical techniques. In addition, they interact with experimental groups in the areas of Physical Chemistry, Biochemistry, and Chemical Biology.


Current Projects
Phospholamban Sarcolipin Protein Kinase A Stannin MD Simulations
Phospholamban
Sarcolipin
Protein Kinase A
Stannin
Molecular Dynamics

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