Veglia group at the University of Minnesota


Phospholamban (WT) Pentamer	Sarcolipin (WT) Monomer	Oriented and Magic Angle Spinning Solid State NMR

Protein Kinase A	NMR Methodology	Molecular Dynamics Simulation


Gianluigi Veglia 5-132 Hasselmo Hall +1-612-625-0758	Wet lab +1-612-626-2089 Lab office +1-612-625-0786 5-256 Hasselmo Hall	Mailing address 6-155 Jackson Hall 321 Church st. SE Minneapolis, MN, 55455	MNMR phones +1-612-625-2715 (Tata Gopinath) +1-612-624-8892 (Spectrometers)

LAB NEWS________________________________________________________________

MEIOSIS family of solid-state NMR experiments 10 May 2013

New paper by Gopinath and GV extends the field of polarization optimized experiments (POE) with the MEIOSIS method. Through recovery of residual polarization on ¹³C and ¹⁵N nuclei via Hadamard encoding it becomes possible to drastically reduce the acquisition time by recording several multidimensional spectra in a single experiment.

Experimental NMR Conference 20 April 2013

Veglia group presented posters at the 54-th Experimental NMR Conference (ENC) at Asilomar, California.

Frank presented an approach for the methyl group assignment.

Gopi reported Hadamard-encoded polarization optimized experiments.

Jonggul demonstrated methyl-based backbone assignments of protein kinase A.

Kaustubh presented an array of experiments aimed at elucidating sarcolipin/SERCA complex.

Vitaly reported on the atomistic details of sarcolipin/SERCA and phospholamban/SERCA interactions.

Gianluigi gave a talk, summarizing the lab's contributions to the field of heart disease research through solid-state NMR methods.

GV gives a talk at Cambridge 13 March 2013

Gianluigi Veglia gave an invited talk on the latest research projects at the Department of Chemistry at the University of Cambridge, UK.

Biophysical Society meeting 12 February 2013

At the 57-th annual meeting of the Biophysical Society in Philadelphia Gianluigi co-chaired a session on Membrane Protein Structure and Function and presented a talk "Molecular details of SERCA regulation by phospholamban revealed by paramagnetic relaxation enhancements and solid-state NMR". Vitaly presented a poster "Characterization of phospholamban mutants implicated in dilated cardiomyopathy".

Paper highlight 24 December 2012

Frank's recent paper on the directed evolution of RNA ligase has been highlighted at Stanford Synchrotron Radiation Lightsource.

Martin defends his Ph.D. thesis 13 December 2012

Martin Gustavsson Martin successfully defended his Ph.D. thesis titled "Characterization of Conformational State of Phospholamban and their Role in Regulation of SR Ca²⁺-ATPase".

Conrgatulations Dr. Gustavsson!!

Our study on an artificial enzyme published in Nature Chemical Biology 8 December 2012

DUMAS-3D This paper by Chao, et al. discusses the primordial fold of an artificially evolved enzyme, Ligase-10C, that catalyzes an unnatural reaction. The study has implications for understanding the evolution of enzymes and catalytic folds, as well as development of artificial enzymes to catalyse reactions.