University of Minnesota
University of Minnesota
http://www.umn.edu/

Go to chemistry home page.

To meet the challenges of antibiotic resistance and specter of a post-antibiotic era, the Carlson lab is pursuing the discovery of the master regulators of bacterial growth and communication and ultimately, the identification of new antibiotics through the application of diverse tools at the interface of chemistry and biology. We are currently pursuing three intersecting objectives: 1) Development and application of powerful strategies to explore and interpret the molecular language used by bacteria to respond to environmental cues using a combination of mass spectrometry, informatics and novel separation reagents, 2) Pursuit of the generation of chemical probes and inhibitors for the global profiling and inhibition of histidine kinases, a ubiquitous class of proteins essential for signal transduction in bacteria, and 3) To deepen our understanding of the multi-protein systems that dictate bacterial growth and division, we are designing selective probes for imaging and proteomics with specific focus on the penicillin-binding proteins. Each of our research objectives is independently important for potential therapeutic development. However, it is our focus on the synergy between multiple areas that is the foundation for our unique ability to detect, interrupt and exploit the master regulators of bacterial behavior.

Projects in Dr. Carlson's research group are highly multidisciplinary and members will gain expertise in many areas including organic synthesis, mass spectrometry, probe and inhibitor design, metabolomics, proteomics, microbiology, biochemistry, imaging and molecular and cellular biology.

Announcements

  • (June, 2016) Latest News The Carlson Lab celebrates their anniversary with a private tour of Surly Brewery! See photos here!
  • (June, 2016) Welcome to undergraduate Ellen Purdy, joining us for the summer as an REU participant with the CSN!
  • (June, 2016) Congratulations to Mani for receiving an Honorable Mention for her poster at the Bioorganic Gordon conference!
  • (May, 2016) Congratulations to Frank and Nikki on their graduation! Frank will pursue his PhD at Indiana University and Nikki will be attending medical school at the University of Wisconsin - Madison!
  • (May, 2016) Congratulations to Ozden on acceptance of her paper in Nature Chemical Biology!
  • (May, 2016) Professor Carlson receives the PECASE award and meets President Obama! Check it out here.
  • (April, 2016) Congratulations to Danica on being awarded the Peteris Auzins Memorial Scholarship for outstanding achievement in undergraduate research, as well as overall scholastic excellence. Congrats!
  • (April, 2016) Professor Carlson was on Minnesota Public Radio in a feature, 'Six things I wish I'd known before starting college.' Check it out!
  • (February, 2016) Congratulations to Katya on passing her candidacy exam! See celebration photos here.
  • (February, 2016) Professor Carlson has been named a Presidential Early Career Awards for Scientists and Engineers (PECASE) recipient by President Barack Obama, the highest honor bestowed by the United States Government on science and engineering professionals in the early stages of their independent research careers. Also see NSF, UMN Chemistry, MN Daily and UMN press releases. See celebration photos here.
  • (January, 2016) Congratulations to Shabnam on passing her candidacy exam! See celebration photos here.
  • (December, 2015) Welcome to undergraduate student Danica Maile!
  • (December, 2015) Congratulations to Kaelyn on publication of her book chapter entitled, "Thiol-ene Enabled Detection of Thiophosphorylation as a Labeling Strategy for Phosphoproteins" in "Phosphoproteomics Methods and Protocols"!
  • (November, 2015) Welcome to first year graduate students Adeline Espinasse, Joe McKillip, Stephanie Mitchell, and Edward Rodionov!
  • (November, 2015) Check out the podcast in Analytical Chemistry about our recent article!
  • (November, 2015) Professor Carlson has been appointed as a Graduate Faculty member of the Department of Biochemistry, Molecular Biology and Biophysics!
  • (November, 2015) Congratulations Andy for being selected the MUACC 2015 Golden Gopher Poster awardee!
  • (October, 2015) The Carlson Group shares the excitment of Natural Products with kids at the Bell Museum! See photos here.
  • (September, 2015) Congratulations to Ashley on defending her thesis! She is officially the fourth PhD from the Carlson Group! See celebration photos here.
  • (September, 2015) Congratulations to Lee on receiving Honorable Mention for teaching the Chemical Biology Lab Course!
  • (August, 2015) The Carlson Group has received funding as a member of The Center for Sustainable Nanotechnology, a multi-institutional research center based at the University of Wisconsin-Madison and including University of Minnesota researchers, that has received $20 million in support over the next five years from the National Science Foundation! Check out this press: Minnesota Daily, UMN Chemistry, and many more!
  • (August, 2015) Nikki Niewold and Ben Willett present posters at the Summer Undergraduate Research Expo!
  • (July, 2015) Congratulations to Andy on being selected as a Baxter Young Investigator!
  • (July, 2015) Congratulations to Ashley on acceptance of her paper in the Journal of the American Society for Mass Spectrometry! See celebration photos here.
  • (July, 2015) Congratulations to Kaelyn on acceptance of her book chapter entitled, "New Approaches to Understanding Bacterial Histidine Kinase Activity and Inhibition" in the upcoming book, "Kinomics: Approaches and Applications"!
  • (July, 2015) Congratulations to Darci on acceptance of her paper in Bioorganic Medicinal Chemistry Letters in the 25th Anniversary Issue Entitled, "Recent Advances in Medicinal Chemistry and Chemical Biology”!
  • (July, 2015) Congratulations to Andy on acceptance of his paper in Analytical Chemistry! See celebration photos here.
  • (July, 2015) The Carlson Lab celebrates their anniversary at a Saint Paul Saints game! See photos here.
  • (June, 2015) Congratulations to Lee on passing his candidacy exam! See celebration photos here.
  • (June, 2015) Welcome to undergraduates Ben Willett and Erick Domingo!
  • (June, 2015) Our first venture into nanotechnology has been published in ACS Central Science!
  • (May, 2015) Professor Carlson has been appointed as a Graduate Faculty member of the Biomedical Informatics and Computational Biology Program!
  • (April, 2015) Congratulations to Nikki and Frank on being selected as winners of the 2015 David and Merece Johnson Scholarship for outstanding achievement!
  • (April, 2015) Congratulations to Nikki and Frank for receiving Undergraduate Research Opportunities Program (UROP) awards. Frank has been awarded funds to work with us this summer and Nikki received funds for the fall semester!
  • (April, 2015) Congratulations to Nikki on her receipt of a Summer Research Fellowship in Chemistry (Heisig/Gleysteen)!
  • (March, 2015) Congratulations to Ozden on acceptance of her second paper in Antimicrobial Agents and Chemotheraphy! See celebration photos here.
  • (March, 2015) Welcome to postdoc Alireza Shokri!
  • (February, 2015) Congratulations to Ozden on acceptance of her paper in Antimicrobial Agents and Chemotheraphy! See celebration photos here.
  • (February, 2015) Professor Carlson has been appointed as a Graduate Faculty member of the Department of Medicinal Chemistry!
  • (February, 2015) Welcome to postdoc Mani Goswami!
  • (January, 2015) Welcome to postdoc Stacy Capehart and undergraduate Nikki Niewold!
  • (December, 2014) Congratulations to Kaelyn on defending her thesis! She is officially the third PhD from the Carlson Group! See celebration photos here.
  • (December, 2014) Congratulations to Kaelyn on acceptance of her paper in ACS Chemical Biology! See celebration photos here.
  • (December, 2014) Congratulations to Ozden on defending her thesis! She is officially the second PhD from the Carlson Group! See celebration photos here.
  • (December, 2014) Professor Carlson presents at the NIH Common Fund High-Risk High-Reward Symposium!
  • (December, 2014) Congratulations to Ashley on receipt of the Agnes Hansen Travel Award from the Xi Chapter of Graduate Women in Science!
  • (December, 2014) Professor Carlson has been elected into the position of Councilor for the Biological Division of the American Chemical Society! For more details, click here.
  • (October, 2014) Congratulations to Ashley on acceptance of her paper in Current Opinions in Chemical Biology! Celebration photos here!
  • (August, 2014) Welcome to Scientist Karen Schmidt!
  • (August, 2014) Welcome to graduate student Katya Konstantynova and undergraduate Frank Roushar!
  • (August, 2014) Congratulations to Ozden on acceptance of her paper that we co-authored with the Winkler Lab in Molecular Microbiology!
  • (July, 2014) Carlson Lab moves to University of Minnesota!
  • (July, 2014) Congratulations to Kaitie for completion of her Master's Degree!
  • (June, 2014) Professor Carlson speaks at the Indonesian-American Kavli Frontiers of Science Symposium organized by the U.S. National Academy of Sciences and the Indonesian Academy of Sciences (AIPI) in Medan, Indonesia!
  • (May, 2014) Congratulations to Andy on acceptance of his paper in ChemComm!
  • (May, 2014) Congratulations to Roxanne for completion of her Master's Degree!
  • (April, 2014) Congratulations to Andy and Kaelyn for being recognized at the chemistry department banquet! Andy was awarded the Henry R. Mahler Memorial Award, given to a student for outstanding research in Chemical Biology/Biochemistry! Kaelyn was recognized for being selected a 2013 Aldrich Graduate Student Innovation Awardee!
  • (April, 2014) Welcome to first year student Shabnam Sharifzadeh!
  • (March, 2014) Professor Carlson speaks at the Gordon Conference on New Antibacterial Discovery & Development: Extending the Antibiotic Era and the ACS Symposium honoring Laura Kiessling for her receipt of the Alfred Bader Award in Bioinorganic or Bioorganic Chemistry!
  • (March, 2014) Congratulations to Darci on acceptance of her paper in Tetrahedron in a Special Issue to honor Sarah Reisman for receipt of the Tetrahedron Young Investigator Award!
  • (February, 2014) Congratulations to Ozden and Kaelyn for being selected to receive the Indiana University Provost Travel Award and Ozden for also receiving a Peglow travel award to attend the upcoming Gordon Conference on New Antibacterial Discovery & Development!
  • (January, 2014) Professor Carlson speaks at the Gordon Conference on Sensory Transduction in Microorganisms!
  • (December, 2013) Congratulations to Andy for passing his fifth semester qualifying exam!
  • (December, 2013) Congratulations to Darci on defending her thesis! She is officially the first PhD from the Carlson Group!
  • (September, 2013) Congratulations to Ozden on acceptance of her paper that we co-authored with the Winkler Lab in Molecular Microbiology and that was selected for the cover!
  • (September, 2013) Congratulations to Kaelyn on acceptance of her perspective in Science Translational Medicine!
  • (September, 2013) The Carlson Lab goes to ACS - Ashley, Andy, Kaelyn, Ozden, Darci, Kaitie and Erin all present!
  • (August, 2013) Congratulations to Ozden and Kaelyn for being selected to receive the IU Provost Travel Award and Kaitie to receive funds from the local section of the ACS (SISACS) to support their attendance of the upcoming ACS meeting in Indianapolis!
  • (August, 2013) Professor Carlson has been invited to attend the First Korean-American Kavli Frontiers of Science Symposium organized by the U.S. National Academy of Sciences and the Korean Academy of Science and Technology!
  • (July, 2013) Congratulations to Kaelyn on being selected a 2013 Aldrich Graduate Student Innovation Awardee!
  • (July, 2013) Congratulations to Ozden on acceptance of her paper in Current Protocols in Chemical Biology!
  • (June, 2013) Congratulations to Ashley for being selected to receive the Indiana University Provost Travel Award to support her attendance of the High-Throughput Screening and Chemical Biology Gordon Conference!
  • (June, 2013) Congratulations to Darci on acceptance of her paper in the Journal of Organic Chemistry!
  • (June, 2013) Congratulations to Ashley, Andy, Jon and Darci on acceptance of their paper in ACS Chemical Biology!
  • (June, 2013) Professor Carlson speaks at the national American Society for Mass Spectrometry meeting!
  • (June, 2013) Welcome to new summer student Raleigh Godsey!
  • (May, 2013) Professor Carlson speaks at the national American Society for Microbiology meeting!
  • (May, 2013) Congratulations to Katie on acceptance of her paper in ACS Chemical Biology!
  • (May, 2013) Professor Carlson was named an Indiana University Dean's Fellow!
  • (May, 2013) Congratulations to Clayton and Joseph for selecting fantastic graduate programs! Clayton will attend Stanford and Joseph is going to Harvard! Check out a graduation photo here.
  • (April, 2013) Congratulations to Katie and Antoinette on acceptance of their paper in the Journal of Chemical Education!
  • (April, 2013) Congratulations to Darci, Andy, Kaelyn, Ozden, Clayton, Jonathan and Joseph for winning chemistry department awards! Darci was recognized for receiving a McCormick Science Grant, Kaelyn and Andy were recognized for their receipt of the QCB Training Grant Fellowship and Kaelyn for receiving a Women in Science Travel Grant. Ozden was awarded the Henry R. Mahler Memorial Award, given to a student for outstanding research in Chemical Biology/Biochemistry and recognized for her receipt of the Marvin Carmack Fellowship, given to an outstanding student in bioorganic chemistry. Jonathan and Joseph were recognized as Honor Roll students, Joseph and Clayton for their participation in the Honors Program and Joseph for being a Phi Beta Kappa inductee. Joseph also received the James C. White Award, given to an exceptional senior student who has participated in research. Jonathan received both the Robert & Marjorie Mann Scholarship and a Hutton Honors College Award. Check out a photo of the award winners here.
  • (March, 2013) Congratulations to Darci on being selected Graduate Student of the Month!
  • (February, 2013) Professor Carlson and our group was recently featured in a video produced by NBC in their Science Behind The News series, a fast-paced video series supported by the National Science Foundation. This piece was one of five videos highlighting work funded by NSF's Directorate for Mathematical and Physical Sciences.
  • (February, 2013) Professor Carlson was named a 2013 Sloan Research Fellow! See our celebration , the Indiana University press release and the New York Times announcement!
  • (February, 2013) Professor Carlson was featured in a "Brilliant Minds" video. Check it out! Also, see a recent blog about the video.
  • Announcement archives