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Metalloprotein Interest Group

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Web Templates 2.0.

Recent Publications

Que Group:

Que graphic
  • Que, L., Jr., "The Road to Non-Heme Oxoferryls and Beyond." Acc. Chem. Res. 2007, 40, 493-500.
  • Xue, G.; Wang, D.; De Hont, R.; Fiedler, A. T.; Shan, X.; Münck, E.; Que, L., Jr., "A Synthetic Precedent for the [FeIV2(m-O)2] Diamond Core Proposed for Methane Monooxygenase Intermediate Q." Proc. Natl. Acad. Sci. USA 2007, 104, 20713-20718.
  • Mas-Ballesté, R.; Que, L., Jr., "Iron-Catalyzed Olefin Epoxidation in the Presence of Acetic Acid: Insights into the Nature of the Metal-Based Oxidant." J. Am. Chem. Soc. 2007, 129, 15964-15972.
  • Sastri, C. V.; Lee, J.; Oh, K.; Lee, Y. J.; Lee, J.; Jackson, T. A.; Ray, K.; Hirao, H.; Shin, W.; Halfen, J. A.; Kim, J.; Que, L., Jr.; Shaik, S.; Nam, W., "Axial ligand tuning of a nonheme iron(IV)-oxo unit for hydrogen atom abstraction." Proc. Natl. Acad. Sci. USA 2007, 104, 19181-19186.
  • Koehntop, K. D.; Marimanikkuppam, S.; Ryle, M. J.; Hausinger, R. P.; Que, L., Jr., "Self-hydroxylation of taurine/a-ketoglutarate dioxygenase: evidence for more than one oxygen activation mechanism." J. Biol. Inorg. Chem. 2006, 11, 63-72.

Lipscomb Group:

Lipscomb graphic
  • Kovaleva, E. G.; Lipscomb, J. D., “Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates.” Science 2007, 316, 453-457.
  • Chakrabarty, S.; Austin, R. N.; Deng, D.; Groves, J. T.; Lipscomb, J. D., “Radical intermediates in monooxygenase reactions of Rieske dioxygenases.” J. Am. Chem. Soc. 2007, 129, 3514-3515.
  • Neibergall, M. B.; Stubna, A.; Mekmouche, Y.; Münck, E.; Lipscomb, J. D., “Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase.” Biochemistry 2007, 46, 8004-8016.
  • Zhang, J.; Wallar, B., J.; Popescu, C., V.; Renner, D., B.; Thomas, D., D.; Lipscomb, J., D., “Methane monooxygenase hydroxylase and B component interactions.” Biochemistry 2006, 45, 2913-2926.
  • Zheng, H.; Lipscomb, J., D., “Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling.” Biochemistry 2006, 45, 1685-1692.

Tolman Group:

Tolman graphic
  • Hong, S.; Huber, S. M.; Gagliardi, L.; Cramer, C. C.; Tolman, W. B., "Copper(I)-a-Ketocarboxylate Complexes: Characterization and O2 Reactions That Yield Copper-Oxygen Intermediates Capable of Hydroxylating Arenes," J. Am. Chem. Soc. 2007, 129, 14190-14192.
  • Bar-Nahum, I.; York, J. T.; Victor G. Young, J.; Tolman, W. B., "Novel Reactivity of Side-On (Disulfido)dicopper Complexes Supported by Bi- and Tridentate Nitrogen Donors: Impact of Axial Coordination," Angew. Chem. Int. Ed. 2008, 47, 533-536.
  • Cramer, C. J.; Tolman, W. B., "Mononuclear CuO2 Complexes: Geometries, Spectroscopic Properties, Electronic Structures, and Reactivity," Acc. Chem. Res. 2007, 40, 601-608.
  • Sarangi, R.; York, J. T.; Helton, M. E.; Fujisawa, K.; Karlin, K. D.; Tolman, W. B.; Hodgson, K. O.; Hedman, B.; Solomon, E. I., "X-Ray Absorption Spectroscopic and Theoretical Studies on (L)2[Cu2(S2)n]2+ Complexes: Disulfide versus Disulfide(1-) Bonding," J. Am. Chem. Soc. 2008, 130, 676-686.
  • Brown, E. C.; Bar-Nahum, I.; York, J. T.; Aboelella, N. W.; Tolman, W. B., "Ligand Structural Effects on Cu2S2 Bonding and Reactivity in Side-On Disulfido-Bridged Dicopper Complexes," Inorg. Chem. 2007, 46, 486-496.

Wilmot Group:

Wilmot Graphic
  • Pearson, A.R.; Elmore, B.O.; Yang, C.; Ferrara, J.D.; Hooper, A.B.; Wilmot, C.M. “The crystal structure of cytochrome P460 of Nitrosomonas europea reveals a novel cytochrome fold and heme-protein cross-link.” Biochemistry 2007, 46, 8340-8349.
  • Johnson, B.J.; Cohen, J.; Welford, R.W.; Pearson, A.R.; Schulten, K.; Klinman, J.P.; Wilmot, C.M. “Exploring molecular oxygen pathways in Hansenula polymorpha copper-containing amine oxidase.” J. Biological Chemistry 2007, 282, 17767-17776.
  • Wilmot, C.M. “An ancient and intimate partnership.” Science 2007, 316, 379-380.
  • Pearson, A.R.; Pahl, R.; Kovaleva, E.G.; Davidson, V.L.; Wilmot, C.M. “Tracking X-ray-derived redox changes in crystals of a methylamine dehydrogenase/amicyanin complex using single-crystal UV/Vis micro-spectrophotometry.“ J. Synchrotron Radiation 2007, 14, 92-98.
  • Pearson, A.R.; Marimanikkuppam, S.; Li, X.; Davidson, V.L.; Wilmot, C.M. “Isotope labeling studies reveal the order of oxygen incorporation into the tryptophan tryptophylquinone cofactor of methylamine dehydrogenase.”J. Am. Chem. Soc. 2006, 128, 12416-12417.

Ohlendorf Group:

Ohlendorf graphic
  • Brown, C. K., M. W. Vetting, C. A. Earhart, and D. H. Ohlendorf, "Biophysical analyses of designed and selected mutants of protocatechuate 3,4-dioxygenase." Annu. Rev. Microbiol. 2004, 58, 555-585.
  • Earhart, C. A., M. W. Vetting, R. Gosu, I. Michaud-Soret, L. J. Que, and D. H. Ohlendorf, "Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla." Biochem. Biophys. Res. Commun. 2005, 338, 198-205.
  • Valley, M. P., C. K. Brown, D. Burk, N. Elango, M. W. Vetting, D. H. Ohlendorf, and J. D. Lipscomb, "Roles of equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis." Biochemistry, 2005, 44, 11024-11039.
  • Vetting, M. W., D. A. D'Argenio, L. N. Ornston, and D. H. Ohlendorf, "Structure of Acinetobacter calcoaceticus protocatechuate 3,4-dioxygenase at 2.2 Å resolution: Implications for the mechanism of an intradiol dioxygenase." Biochemistry, 2000, 39, 7943-7955.
  • Vetting, M. W., and D. H. Ohlendorf, "The 1.8 Å crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker." Structure Fold. Des. 2000, 8, 429-440.

Pierre Group:

Pierre graphic
  • Pierre, V. C.; Kaiser, J. T.; Barton, J. K. “DNA bound by a Rhodium Intercalator: Structural Insights into Finding a Mismatch” Proc. Natl. Acad. Sci. USA 2007, 104, 429-434.
  • Pierre, V. C.; Botta, M.; Aime, S.; Raymond, K. N. “Substituent Effects on Gd(III)-based MRI Contrast Agents – Optimizing the Stability of the Complex and the Number and Exchange Rate of Coordinated Water Molecules” Inorg. Chem. 2006, 45, 8355-8364.
  • Pierre, V. C.; Botta, M.; Aime, S.; Raymond, K. N. “Fe(III) Templated Gd(III) Self-Assemblies – a New Route Toward Macromolecular MRI Contrast Agents” J. Am. Chem. Soc. 2006, 128, 9272-9273.
  • Pierre, V. C.; Botta, M.; Aime, S.; Raymond, K. N. “Tuning the Coordination Number of Hydroxypyridonate-based Gadolinium Complexes – Implications for MRI Contrast Agents” J. Am. Chem. Soc. 2006, 128, 5344-5345.
  • Pierre, V. C.; Botta, M.; Raymond, K. N. “A Dendrimeric Gadolinium Chelate with Fast Water Exchange and High Relaxivity at High Magnetic Field Strength”  J. Am. Chem. Soc. 2005, 127, 504-505.

Hooper Group:

  • Bergmann, D.J. and Hooper, A.B. "Cytochrome P460 of Nitrosomonas europaea: Formation of the Heme-Lysine Cross-link in a Heterologous Host and Mutagenic Conversion to a Non-Cross-linked Cytochrome c’"  Eur. J. Bioch. 2003, 270, 1935 – 1941.       
  • Hooper, A.B., Arciero, D.M., Bergmann, D., and Hendrich, M.P. "The Oxidation of Ammonia as an Energy Source in Bacteria in Respiration" in Davide Zannoni, Ed. Respiration in Archaea and Bacteria: Diversity of Procaryotic Respiratory Systems pp 121 – 147. Vol 16 of Advances in Photosynthesis and Respiration, Govindjee, Ed.   Springer,  Dordrecht, the Netherlands (2005).
  • Bergmann, D.B., Hooper, A.B. and Klotz, M., "Structure and Sequence Conservation of hao Cluster Genes of Autotrophic Ammonia-Oxidizing Bacteria: Evidence for their Evolutionary History" Appl. Envt. Microbiol. 2005, 71, 5371 – 5382.
  • Elmore, B , Bergmann, D.B., Klotz, M., and Hooper, A.B.  "Cytochromes-P460 and -c’-beta; a New Family of High-spin cytochromes c" FEBS Lett 2007, 581, 911-916.
  • Pearson, A.R., Elmore, B.O., Yang, C., Ferrara, J.D., Hooper, A.B. & Wilmot, C.M. "The crystal structure of cytochrome P460 of Nitrosomonas europea reveals a novel cytochrome fold and heme-protein cross-link" Biochemistry 2007, 46, 8340-8349.

Lu Group:

  • Lu, C. C.; DeBeer George, S.; Weyhermüller, T.; Bill, E.; Bothe, E.; Wieghardt, K. “An Electron-Transfer Series of High-valent Chromium Complexes with Redox Non-innocent, Non-heme Ligands.” Angew. Chem. Int. Ed. Engl. 2008, 47, 6384-6387.       
  • Lu, C. C.; Bill, E.; Weyhermüller, T.;  Bothe, E.; Wieghardt, K. “Neutral Bis(alpha-iminopyridine)metal Complexes of the First-row Transition Ions (Cr, Mn, Fe, Co, Ni, Zn) and Their Monocationic Analogues: Mixed Valency Involving a Redox Non-innocent Ligand System.” J. Am. Chem. Soc. 2008, 130, 3181-3197
  • Lu, C. C.; Bill, E.; Weyhermüller, T.; Bothe, E.; Wieghardt, K. “The Monoanionic pi-Radical Redox State of alpha-Iminoketones in Bis(ligand)metal Complexes of Nickel and Cobalt.” Inorg. Chem. 2007, 46, 7880-7889.
  • Lu, C. C.; Saouma, C. T.; Day, M. W.; Peters, J. C.  "Fe(I)-mediated Reductive Cleavage and Coupling of CO2: An Fe(II)(mu-O, mu-CO)Fe(II) Core." J. Am. Chem. Soc. 2007, 129, 4-5.
  • Lu, C. C.; Peters, J. C.  "Pseudotetrahedral Manganese Complexes Supported by the Anionic Tris(phosphino)borate ligand [PhBP(iPr)3]."  Inorg. Chem. 2006, 45, 8597 - 8607.

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News Items and Research Commentaries

 

Research News: In work that appears in the May 27, 2008 issue of Proceedings of the National Academy of Sciences USA (Proc. Natl. Acad. Sci. USA 2008, 105, 7347-7352), postdoctoral associates Joseph Emerson and Elena Kovaleva, together with graduate student Erik Farquhar, in the groups of Profs. Larry Que and John Lipscomb report the surprising observation that the metal centers of a pair of iron- and manganese-dependent dioxygenases, namely Fe-HPCD and Mn-MndD, can be swapped without affecting the catalytic parameters of these enzymes.

Recent results from the Tolman group are discussed in a "Highlights" article: Rolff, M.; Tuczek, F., "How Do Copper Enzymes Hydroxylate Aliphatic Substrates? Recent Insights from the Chemistry of Model Systems,"Angew. Chem. Int. Ed. 2008, 47, 2344-2347.

Research News: The first synthetic complex with a [FeIV2(μ-O)2] diamond core. (Que group)

Research News: A Copper-Oxo Intermediate from O2? (Tolman/Cramer groups)

Research News: FeV=O in Bio-inspired Olefin Epoxidation Catalysis. (Que group)

C&EN Commentary (4/07) "A Crystal With A Story to Tell" (Lipscomb group)

Perspective on Lipscomb group results: Wilmot, C. M. "An ancient and intimate partnership," Science 2007, 316, 379-380. (Free access through this link)

Carrie Wilmot is featured in a USA Today news article by science reporter Dan Vergano entitled "Chemists pump iron for answers about life in the universe". Check it out on-line at USA Today's website.

Read about Carrie Wilmot in the Winter 2006-2007 issue of BiO, the College of Biological Sciences award winning magazine.