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Metalloprotein Interest Group

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Web Templates 2.0.

Recent Publications

Que Group:

Que graphic
  • McDonald, A. R.; Que, L., Jr. "High-Valent Nonheme Iron-Oxo Complexes: Synthesis, Structure, and Spectroscopy. Coord." Chem. Rev. 2013, 257, 414-428(10.1016/j.ccr.2012.08.002).
  • Wang, D.; Ray, K.; Collins, M. J.; Farquhar, E. R.; Frisch, J. R.; Gómez, L.; Jackson, T. A.; Kerscher, M.; Waleska, A.; Comba, P.; Costas, M.; Que, L., Jr. "Nonheme Oxoiron(IV) Complexes of Pentadentate N5 Ligands: Spectroscopy, Electrochemistry, and Oxidative Reactivity." Chem. Sci. 2013, 4, 282-291 (10.1039/C2SC21318D; PMC3515645).
  • Frisch, J. R.; McDonnell, R.; Rybak-Akimova, E. V.; Que, L., Jr. "Factors Affecting the Carboxylate Shift upon Formation of Nonheme Diiron-O2 Adducts." Inorg. Chem. 2013,52, accepted for publication.
  • Cranswick, M. A.; Meier, K. K.; Shan, X.; Stubna, A.; Kaizer, J.; Mehn, M.P.; Münck, E.; Que, L. Jr. "Protonation of a Peroxodiiron(III) Complex and Conversion to a Diiron(III/IV) Intermediate: Implications for Proton-Assisted O−O Bond Cleavage in Nonheme Diiron Enzymes." Inorg. Chem. 2012, 51, 10417-10426 (10.1021/ic301642w; PMC3462276).
  • Shanmugam, M.; Xue, G.; Que, L., Jr.; Hoffman, B.M. 1H-ENDOR Evidence for a Hydrogen Bonding Interaction that Modulates the Reactivity of a Non-heme FeIV=O Unit." Inorg. Chem. 2012, 51, 10080-10082 (10.1021/ic3015783; PMC3482979).

Lipscomb Group:

Lipscomb graphic
  • Kovaleva, E.G.; Lipscomb, J.D., “Crystal Structures of Fe2+ Dioxygenase Superoxo, Alkylperoxo, and Bound Product Intermediates.” Science 2007, 316, 453-457.
  • Chakrabarty, S.; Austin, R.N.; Deng, D.; Groves, J.T.; Lipscomb, J D., “Radical Intermediates in Monooxygenase Reactions of Rieske Dioxygenases.” J. Am. Chem. Soc. 2007, 129, 3514-3515.
  • Neibergall, M.B.; Stubna, A.; Mekmouche, Y.; Münck, E.; Lipscomb, J D., “Hydrogen Peroxide Dependent CIS-dihydroxylation of Benzoate by Fully Oxidized Benzoate 1,2-dioxygenase.” Biochemistry 2007, 46, 8004-8016.
  • Zhang, J.; Wallar, B.J.; Popescu, C.V.; Renner, D.B.; Thomas, D.D.; Lipscomb, J.D., “Methane Monooxygenase Hydroxylase and B Component Interactions.” Biochemistry 2006, 45, 2913-2926.
  • Zheng, H.; Lipscomb, J.D., “Regulation of Methane Monooxygenase Catalysis Based on Size Exclusion and Quantum Tunneling.” Biochemistry 2006, 45, 1685-1692.

Tolman Group:

Tolman graphic
  • Gupta, A.K.; Tolman, B. "Cu(I)/O2 Chemistry Using a b-Diketiminate Supporting Ligand Derived from N,N-Dimethylhydrazine: Identification of a [Cu3O2]3+ Complex with Novel Reactivity." Inorg. Chem. 50, 1881–1888.
  • Yang, L.; Tolman, B."Type 1 Copper Site Synthetic Model Complexes with Increased Redox Potentials."J. Biol. Inorg. Chem. 2012, 17, 285-291.
  • Donoghue, P.J.; Tehranchi, J.; Cramer, C.J.; Sarangi, R.; Solomon, E.I.; Tolman, W.B. "Rapid C-H Bond Activation by a Monocopper(III)-Hydroxide Complex". J. Am. Chem. Soc. 2011, 133, 17602–17605.
  • Sarangi, R.; Yang, L.; Kohl, S.G.; Gagliardi, L.; Cramer, C.J.; Tolman, W.B.;Solomon, E.I. "X-ray Absorption Spectroscopic and Computational Investigation of a Possible S…S Interaction in the [Cu3S2]3+ Core." J. Am. Chem. Soc., 2011, 133, 17180–17191.
  • Yang, L.; Tehranchi, J.; Tolman,W.B. "Reactions of Ph3Sb=S with Copper(I) Complexes Supported by N-Donor Ligands: Formation of Stable Adducts and S-Transfer Reactivity". Inorg. Chem., 2011, 50, 2606-2612.

Wilmot Group:

Wilmot Graphic
  • Yukl, E.; Liu, F; Krzystek,J.; Shin, S.; Jensen, L.; Davidson, V.; Wilmot, C.; Liu, A. "A Di-radical Intermediate within the Context of Tryptophan Tryptophylquinone Biosynthesis." Natl. Acad. Sci. USA, in press.
  • Jensen, L.M.R.; Meharenna, Y.T.; Davidson, V.L.; Poulos, T.L.; Hedman, B.; Wilmot, C.M.; Sarangi, R. (2012) "Geometric and Electronic Structures of the His-Fe(IV)=O and His-Fe(IV)-Tyr Heme of MauG." J. Biol. Inorg. Chem. 17:1241-1255.
  • Tarboush, N.A.; Jensen, L.M.R; Yukl, E.T.; Geng, J.; Liu A.; Wilmot, C.M.; Davidson, V.L. (2011) "Mutagenesis of Tryptophan199 Suggests that Hopping is Required for MauG-dependent Tryptophan Tryptophylquinone Biosynthesis." Proc. Natl. Acad. Sci. USA 108: 16956-16961.
  • Cedervall, P.E.; Dey, M.; Li, X.; Sarangi, R.; Hedman, B.; Ragsdale, S.W.; Wilmot, C.M. (2011) Structural Analysis of a Ni-methyl Species in Methyl-coenzyme M Reductase from Methanothermobacter Marburgensis." J. Am. Chem. Soc. 133: 5626-5628.
  • Goblirsch, B.R.; Kurker, R.C.; Streit, B.R.; Wilmot, C.M.; DuBois, J.L. (2011) "Chlorite Dismutases, DyPs, and EfeB: 3 Microbial Heme Enzyme Families Comprise the CDE Structural Superfamily." J. Mol. Biol. 408: 379-398.
  • Goblirsch, B.R.; Streit, B.R.; DuBois, J.L.; Wilmot, C.M. (2010) "Structural Features Promoting Dioxygen Production by Dechloromonas Aromatica Chlorite Dismutase." J. Biol. Inorg. Chem. 15: 879-888.
  • Jensen, L.M.R.; Sanishvili, R.; Davidson, V.L.; Wilmot, C.M. (2010) "In Crystallo Posttranslational Modification within a MauG/Pre-methylamine Dehydrogenase Complex." Science 327: 1392-1394.

Ohlendorf Group:

Ohlendorf graphic
  • Brown, C. K., M. W. Vetting, C. A. Earhart, and D. H. Ohlendorf, "Biophysical analyses of designed and selected mutants of protocatechuate 3,4-dioxygenase." Annu. Rev. Microbiol. 2004, 58, 555-585.
  • Earhart, C. A., M. W. Vetting, R. Gosu, I. Michaud-Soret, L. J. Que, and D. H. Ohlendorf, "Structure of catechol 1,2-dioxygenase from Pseudomonas arvilla." Biochem. Biophys. Res. Commun. 2005, 338, 198-205.
  • Valley, M. P., C. K. Brown, D. Burk, N. Elango, M. W. Vetting, D. H. Ohlendorf, and J. D. Lipscomb, "Roles of equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis." Biochemistry, 2005, 44, 11024-11039.
  • Vetting, M. W., D. A. D'Argenio, L. N. Ornston, and D. H. Ohlendorf, "Structure of Acinetobacter calcoaceticus protocatechuate 3,4-dioxygenase at 2.2 Å resolution: Implications for the mechanism of an intradiol dioxygenase." Biochemistry, 2000, 39, 7943-7955.
  • Vetting, M. W., and D. H. Ohlendorf, "The 1.8 Å crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker." Structure Fold. Des. 2000, 8, 429-440.

Pierre Group:

  • Weitz, E.A.; Chang, J.Y.; Rosenfield, A.; Pierre, V.C.* “A Selective Luminescent Sensor for the Time-Gated Detection of ATP” J. Am. Chem. Soc. 2012, 134, 16099-16102.
  • Smolensky, E.D.; Marjanska, M.; Pierre, V.C.* “A Responsive Particulate MRI Contrast Agent for Copper(I): A Cautionary Tale” – Dalton Trans., 2012, 41, 8039-8046. (invited contributions “New Talents in Americas”)
  • Smolensky, E.D.; Zhou, Y.; Pierre, V.C.* “Magnetoluminescent Agents for Dual MRI and Time-Gated Fluorescence Imaging” Eur. J. Inorg. Chem., 2012, 12, 2141-2147. (invited contribution – special issue on “metal-based MRI probes” – highlighted in ChemViews: http://www.chemistryviews.org/details/ezine/1653063/Two-in-One_Imaging_Agents.html)
  • Smolensky, E.D.; Neary, M.C.; Zhou, Y.; Berquo, T.S.; Pierre, V.C.* “Fe3O4@organic@Au: High Saturation Magnetization Core-Shell Nanocomposites as Magnetoplasmonic MRI Contrast Agents” Chem. Commun. 2011, 47, 2149-2151.
  • Weitz, E.A.; Pierre, V.C.* “A Ratiometric Probe for the Time-Gated Luminescence Detection of Potassium in Water” Chem. Commun. 2011, 47, 541-543. (invited contribution – special issue on emerging investigators)
  • Smolensky, E.D.; Park, H.-Y.E.; Berquo, T.S.; Pierre, V.C.* “Surface Functionalization of Iron Oxide Nanoparticles for MRI Applications: Effect of Anchoring Group and Ligand Exchange Protocol” Contrast Agents Mol. Imaging 2011, 6, 189-199.
  • Page, S.E.; Wilke, K.T.; Pierre, V.C.* “A Selective and Sensitive Luminescent Probe for the Time-Gated Detection of Hydroxyl Radical in Water” Chem. Commun. 2010, 46, 2423-2425.

Hooper Group:

  • Basumallick,  L.; Sarangi, R.; Elmore, B.; Hooper, A.B.; Solomon, E.I.   "Spectroscopic and Density Functional Studies of the Red Copper Site in Nitrosocyanin: Role of the Protein in Active site Geometric and Electronic Structure," J. Am. Chem. Soc.2005, 127, 3531-3544.
  • Pulcu, G.S.; Elmore, B.L.; Arciero, D.M.; Hooper, A.B.; Elliot, S.J. "Direct electrochemistry of tetraheme cytochrome c554 from Nitrosomonas europaea: redox cooperativity and conformational gating." J. Am. Chem. Soc. 2007, 129, 1838-1839.       
  • Pearson, A.R.; Elmore, B.O.; Yang, C.; Ferrara, J.D.; Hooper, A.B.; Wilmot, C.M. "The crystal structure of cytochrome P460 of Nitrosomonas europea reveals a novel cytochrome fold and heme-protein cross-link." Biochemistry, 2007, 46, 8340-8349.
  • Kim, H. J.; Zatsman, A.; Upadhyay, A. K.;  Whittaker, M.W.; Bergmann, D.J.;  Hendrich, M.P.; Hooper, A.B. " Membrane Tetraheme Cytochrome cm552 of the Ammonia-Oxidizing Nitrosomonas europaea; a Ubiquinone Reductase." Biochemistry, 2008, 47, 6539-6551.
  • Klotz, M.G.; Schmid, M.C.; Strous, M.; op den Camp, H.J.M.; Jetten, M.S.M.; Hooper, A.B. " Evolution of an octaheme cytochrome c protein family that is key to aerobic and anaerobic ammonia oxidation by bacteri.", Environmental Microbiology, 2008, 10, 3150-3163.

Lu Group:

  • Rudd, P.A.; Liu, S.; Planas, N.; Bill, E.; Gagliardi, L.; Lu, C.C. "Multiple Metal-Metal Bonds in Iron-Chromium Complexes." Angew. Chem. Int. Ed. Engl. 2013, in press.
  • Saouma, C.T.; Lu, C.C.; Peters, J.C. "Mononuclear Five- and Six-Coordinate Iron Hydrazido and Hydrazine Species." Inorg. Chem. 2012, 51, 10043-10054.
  • Tereniak, S.J.; Marlier, E E.; Lu, C.C. "One-electron Ni(II)/(I) Redox Couple: Potential Role in Hydrogen Activation and Production." Dalton Trans. 2012, 41, 7862-7865 (New Talent: Americas issue).
  • Miller, D.L.; Lu, C.C. "Encapsulating Zinc(II) within a Hydrophobic Cavity." Dalton Trans. 2012, 41, 7464-7466.
  • Zall, C.M.; Zherebetskyy, D.; Dzubak, A.L.; Bill, E.; Gagliardi, L.; Lu, C.C. "A Combined Spectroscopic and Computational Study of a High-spin S = 7/2 Diiron Complex with a Short Iron-Iron Bond." Inorg. Chem. 2012, 51, 728-736. http://dx.doi.org/10.1021/ic202384b
  • Rudd, P.A.; Liu, S.; Gagliardi, L.; Young, V G., Jr.; Lu, C.C. "Metal-Alane Adducts with Zero-Valent Nickel, Cobalt, and Iron." J. Am. Chem. Soc. 2011, 133, 20724-20727.

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News Items

Lu receives Alfred P. Sloan Research Fellowship

Connie Lu, assistant professor in the Department of Chemistry, has been awarded a prestigious Alfred P. Sloan Research Fellowship for 2013. Lu was among 126 winners of this highly competitive award intended to enhance the careers of exceptional young faculty, including two other honorees from the University of Minnesota.

Sloan Fellowship winners are faculty members at 59 colleges and universities in the United States and Canada who are conducting pioneering research in physics, chemistry, computational and evolutionary molecular biology, computer science, economics, mathematics, and neuroscience. Each winner receives a grant of $50,000 for a two-year period.

Sloan Research Fellows are free to pursue whatever lines of inquiry are of most interest to them, and they are permitted to employ fellowship funds in a variety of ways to further their research aims.

Pierre receives Translational Grant Award

Professor Valerie Pierre has received a fall 2012 Translational Grant Award from the University of Minnesota's Clinical and Translational Science Institute (CTSI). Her research encompasses siderophore aptasensors for immediate point-of-care diagnosis of urinary tract infections.

This round of awards, designed to facilitate the highest quality translational research, was dedicated to junior investigators at the University of Minnesota. Pierre was one of four researchers to receive a grant.

In translational research, scientific discoveries are moved from the laboratory into real-world practice, leading to improved human health.

Pierre will partner with a project development team from the CTSI Office of Discovery and Translation (ODAT), which will provide project mapping and translational research expertise to facilitate the achievement of specific metrics and endpoints.



Research News: In work that appears in the May 27, 2008 issue of Proceedings of the National Academy of Sciences USA (Proc. Natl. Acad. Sci. USA 2008, 105, 7347-7352), postdoctoral associates Joseph Emerson and Elena Kovaleva, together with graduate student Erik Farquhar, in the groups of Profs. Larry Que and John Lipscomb report the surprising observation that the metal centers of a pair of iron- and manganese-dependent dioxygenases, namely Fe-HPCD and Mn-MndD, can be swapped without affecting the catalytic parameters of these enzymes.

Recent results from the Tolman group are discussed in a "Highlights" article: Rolff, M.; Tuczek, F., "How Do Copper Enzymes Hydroxylate Aliphatic Substrates? Recent Insights from the Chemistry of Model Systems,"Angew. Chem. Int. Ed. 2008, 47, 2344-2347.

Research News: The first synthetic complex with a [FeIV2(μ-O)2] diamond core. (Que group)

Research News: A Copper-Oxo Intermediate from O2? (Tolman/Cramer groups)

Research News: FeV=O in Bio-inspired Olefin Epoxidation Catalysis. (Que group)

C&EN Commentary (4/07) "A Crystal With A Story to Tell" (Lipscomb group)

Perspective on Lipscomb group results: Wilmot, C. M. "An ancient and intimate partnership," Science 2007, 316, 379-380. (Free access through this link)

Carrie Wilmot is featured in a USA Today news article by science reporter Dan Vergano entitled "Chemists pump iron for answers about life in the universe". Check it out on-line at USA Today's website.

Read about Carrie Wilmot in the Winter 2006-2007 issue of BiO, the College of Biological Sciences award winning magazine.